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Scientist/Senior Associate Scientist, Analytical Development

Process and Product Development | South San Francisco, CA | Full Time

Job Description

About Allogene Therapeutics, Inc:

Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.

Job Description:

Allogene is seeking a Senior Associate Scientist or Scientist to join our Analytical Development group and contribute to the commercialization of allogenic CAR T therapies. The incumbent will play a key role in CAR T cell therapy related analytical assay development and execution of drug product release assays.

Responsibilities include, but are not limited to:

  • Generate table cell line and make master and working cell bank
  • Design and perform immune cell-based assays
  • Design and contribute to CAR T cell characterization by cytotoxicity, cytokine release, and flow cytometry
  • Support drug product release and stability tests
  • development and optimize assay conditions for T cell selection, genomic manipulation, cell expansion and cryopreservation
  • Review and contribute to authoring of SOPs, test reports, raw material specifications, patent disclosures and regulatory submissions
  • Refine pre-IND clinical programs through cross-functional collaborations with Research, Process Development and other vested parties
  • working collaboratively across various project teams to meet deadline-dependent milestones
  • Implement Quality by Design methodology to support BLA and commercialization

Position Requirements & Experience:

  • Bachelor’s Degree with 5+ years or Master’s Degree with 2+ years of relevant cell biology, immunology or biochemistry experience
  • Self-motivated, detail-orientated, and eager to be part of a positive work environment with other researchers to develop allogeneic CAR T cell therapies targeting cancer.
  • Cell culture techniques and cell banking experience
  • Specific experience with quantitative analytical techniques including qPCR, ddPCR, ELISA and fluorescence-based enzymatic assays
  • Ability to work independently and as part of a team
  • Prior working knowledge in assay development is a plus
  • Cell and gene therapy experience a plus
  • Working knowledge of Quality control and GMP requirements is a plus
  • Candidates must be authorized to work in the U.S.

As an equal opportunity employer, Allogene Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact the careers email at www.allogene.com for assistance.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.


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