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Senior Scientist II/Medicinal Chemistry

Nonclinical Research and Development | Mountain View, CA | Full Time

Job Description

Job Description: Senior Scientist II/Medicinal Chemistry

Do you want to grow a company that positively impacts the world? At twoXAR Pharmaceuticals, we discover and develop first-in-class small molecules. We are seeking talented and highly motivated individuals with a strong background in synthetic organic chemistry to join our medicinal chemistry group in the pursuit of developing novel small molecules to treat patients with unmet medical needs. The successful candidate will have a PhD and extensive knowledge and experience in the drug discovery and optimization process, with at least 10 -12 years of experience in identifying NCE. The qualified candidate will be responsible for contributing to the medicinal chemistry scientific excellence, fostering innovation and cross-functional collaboration with both internal and external scientific community.

twoXAR is an AI-driven drug discovery and development company focused on first-in-class small molecules. The company currently has a development portfolio of over 18 diseases. twoXAR saves years in drug development while generating a 30x hit rate at in vivo efficacy milestones over traditional methods. We have established collaborations with leading biopharmaceutical companies and are now scaling the business and building our internal drug pipeline. twoXAR is venture-backed with financing from SoftBank Ventures and Andreessen Horowitz and has strong ties to Stanford University and MIT. Our management team and advisory board have decades of biopharmaceutical management experience, built software systems used by tens of millions of people, held VP and C-level positions at Fortune 100 companies, and have had previous startups with successful strategic acquisitions.


  • The successful candidate will be responsible for driving medicinal chemistry research during the lead identification and optimization stage as part of a drug discovery team. ┬áSpecifically, this individual will design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy.

  • Contribute to evaluation, optimization and assist in management of external chemistry CRO resources

  • Manage compound synthesis, SAR interpretation, design with CRO teams to meet lead candidate selection timelines

  • Assist in oversight of external medicinal chemistry resource to advance small molecule drug discovery projects to critical decision-making milestones, from lead identification, lead optimization and identification to clinical candidate selection

  • Support the development of clinical candidates through designing synthetic routes, optimization of chemical leads through utilization of SAR, structure-based design for potency and selectivity optimization

  • Manage and mentor junior level scientists


  • Ph.D. in synthetic organic chemistry, medicinal chemistry with 10-12 years of experience preferably in pharma/biotech

  • Successful application of structure-based drug design leading to advanced leads, and/or development candidates. Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of computational tools, models and visualization applications.

  • High level of creativity and productivity with strong synthetic problem-solving skills

  • Excellent scientific expertise in organic synthesis, conversant with the current literature

  • Solid track record of innovation and impact on programs, with direct contributions to company pipelines (including both successful advances and smart terminations).

  • Ability to make inventive contributions towards new chemical target structures or templates for programs and employ sound judgment in the evaluation and strategic decision making around early screening or literature hits.

  • Excellent knowledge of medicinal chemistry principles with a solid understanding of the basic biology and pharmacology of programs, and the ADME issues. Able to effectively integrate this knowledge and apply the key principles of medicinal chemistry, literature precedent, and drug design to direct medicinal chemistry programs to phase transitions or series go/no go decisions.

  • Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy.

  • Excellent communication skills and able to present the rationale, key data, issues, and accomplishments of the chemistry efforts to other members of the department.

twoXAR is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.