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Summer Undergraduate Internship - Assay and Screening

Summer Internships | Berkeley, CA | Internship

Job Description

This is a summer internship for undergraduate students who will still be in an undergraduate program in the Fall of 2018.  

The Assay and Screening intern will learn how to develop and optimize a biochemical and cellular assay for an enzyme that has been identified as a drug target in the field of oncology. The ideal candidate will have a strong background in biology with knowledge of the immune system. He or she will work in close collaboration with a scientist in the group and become familiar with general lab and safety procedures employed in an active drug discovery organization. The intern will keep meticulous records in an electronic lab notebook and progress reports are given in weekly group meetings. The intern will perform routine high-throughput biochemical assays to screen compounds for a select drug target. He or she will be involved in the optimization process which includes characterizing buffer composition, reaction time and temperature, enzyme, and substrate and detection reagent concentrations. In addition, the intern will perform cellular-based assays to evaluate the expected biological response before testing the drug candidate in vivo. The intern will first become familiar with general cell culture and safety procedures for handling biological materials and help by keeping various cell lines in culture. Once the intern has established this skill set, he or she will perform more exploratory assays using various cellular populations. The intern will perform multi-color flow cytometry to characterize the phenotype of cell lines and/or primary human immune cells in the presence or absence of compound. He or she will also perform other assays to characterize the immune response such as ELISAs and/or multiplex protein arrays. He or she will become familiar with the methodology and criteria used to obtain robust assays, data analysis and quality control.

At the end of the internship, the developed assays are taken into production to determine the potency of our in house compounds. A final presentation is given for the Discovery Biology department and the company Research Meeting.

Company Description:

Plexxikon, a member of the Daiichi Sankyo Group, is a leader in the discovery and development of novel, small molecule pharmaceuticals. The company utilizes its proprietary discovery platform to successfully develop a portfolio of competitively differentiated clinical and preclinical stage compounds in a number of therapeutic areas. Plexxikon’s most advanced program, Zelboraf™ (vemurafenib) was the first oral targeted therapy to be approved for the treatment of both metastatic and unresectable melanomas.   Plexxikon's demonstrated capability in discovery and early development uniquely positions the company to develop multiple commercial franchises for different therapeutic indications, and to create significant value for Plexxikon, Daiichi Sankyo and its collaborators.

Plexxikon's novel discovery approach, combined with experienced management and scientific teams, a broad network of scientific and clinical experts, and partnerships supporting later stage development, have been key drivers of the company's success since it began operations in 2001.  Plexxikon is a small business with approximately 70 employees based in Berkeley, California.

Summer 2018 will be Plexxikon’s fourteenth year of participation in the undergraduate summer internship program, having experienced highly successful results in each previous year.   This is a paid internship that will run from Friday, June 1 – Friday, August 11, 2018. Our office is just off I80 at University Avenue.   Please find out more at: