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Director, Research

Research Operations | San Francisco, Ca | Full Time

Job Description

About Us

 The Parker Institute for Cancer Immunotherapy (PICI) is radically changing the way cancer research is done. Founded in 2016 through a $250 million gift from Silicon Valley entrepreneur and philanthropist Sean Parker, the San Francisco-based nonprofit is an unprecedented collaboration between the country’s leading immunotherapy researchers and cancer centers, including Memorial Sloan Kettering Cancer Center, Stanford Medicine, the University of California, Los Angeles, the University of California, San Francisco, the University of Pennsylvania and The University of Texas MD Anderson Cancer Center. The institute also supports top researchers at other institutions, including City of Hope, Dana-Farber Cancer Institute, Fred Hutchinson Cancer Research Center, Icahn School of Medicine at Mount Sinai, Institute for Systems Biology and Washington University School of Medicine in St. Louis.

By forging alliances with academic, industry and nonprofit partners, PICI makes big bets on bold research to fulfill its mission: to accelerate the development of breakthrough immune therapies to turn all cancers into curable diseases.

Help us create a world that doesn’t fear cancer. Join us.

 Overview of the Role

 The Director, Research is both a strategic and tactical role providing guidance and ensures execution across the field of Immuno-Oncology and implements specific, approved collaborations, projects and programs.  This position will support PICI’s overall strategic approach to include new cutting-edge technological areas with a potential for impactful advances in IO therapies.  In addition, this position will be central in the scientific/research leadership of clinical trial cross functional teams and management of key relationships across the institute.

 Reporting Structure and Team

The Director of Research reports to the VP, Research and Development and is a key research member of Cross Functional Program teams.

FLSA Status: Exempt

Essential Job Functions

  • Evaluate new and developing technologies in multiple scientific fields, with a focus on interdisciplinary solutions in support of PICI’s effort in novel immunotherapy combinations and adoptive cellular therapy, including:
    • TME manipulation
    • Immune suppression modulation
    • Immune stimulation
  • As time permits:
    • Provide technical awareness, scientific leadership, and ensure state-of-the-art competency within I/O area.
    • Collaboration with PICI clinical project teams to ensure appropriate trial design and mechanistic assay implementation.
    • Use personal network to contribute to the identification of new project opportunities from external partners in academia or the biotech industry.
    • Participate in the evaluation of new project opportunities presented by Member Researchers and external partners.
    • Actively review patents and patent applications in areas of research relevance and identify opportunities.
    • In compliance with the research strategy, and in collaboration with the project teams, identify and expand external research contacts.
    • Ensure appropriate scientific representation at external scientific meetings, conferences, etc.
    • Participation in setting direction and evaluating drugs and technologies in support of the Institute’s focus areas, which include:
      • Adoptive Cell Therapies
        • Target Discovery and Validation
        • Gene regulation
        • CMC processes
      • Checkpoint blockade
        • Next-generation inhibitory receptors
        • Mechanistic analyses of responses
        • Rational combination therapies
      • Antigen Discovery and Vaccine development
        • Neoantigen pipeline validation
        • Approaches to shared antigen discovery
        • Vaccine technologies
      • Characterization and modification of the TME
        • Novel technologies to understand the role of the TME
        • Characterization and control of the metabolism associated with the tumor microenvironment

 Knowledge, Skills, and Experience

  • PhD in Immunology or an associated area and at least 10 years of relevant work experience
  • Some industry or biotech experience is preferred
  • Broad, detailed understanding of field that has resulted in a solid track record of generating critical data, innovations of tangible benefit to research programs, and/or initiation of projects/programs
  • Solid technical background with understanding and hands-on experience with immunology
  • Visible contributor to external scientific community through patents, publications, invited talks, and/or collaborations
  • Innovative approach in both scientific research and in problem solving
  • Ability to influence, lead and manage conflict
  • Ability to adapt to changes
  • Ability to handle stress and work on multiple projects simultaneously
  • Excellent client-facing and internal communication skills, both written and verbal