Senior Research Associate II, Molecular Biology
Molecular Biology | Emeryville, CA | Full Time | From $114,000.00 to $127,000.00 per year
About OmniAb
OmniAb provides our pharmaceutical industry partners access to the most diverse antibody repertoires and cutting-edge screening technologies to enable discovery of next-generation therapeutics. We leverage our state-of-the-art technologies to facilitate the discovery of best-in-class antibodies. Within OmniAb are also core capabilities for the discovery and screening of high-value ion channel and transporter targets.
OmniAb consists of dynamic, collaborative and innovative team members that are passionate about contributing to the technological frontier of drug discovery and to the advancement of global human health. Together, with our partners, we are enabling the discovery of next-generation therapeutics.
About This Role
We’re seeking a Senior Research Associate II, Molecular Biology, who be responsible for assisting in the creation and validation of transgenic chickens expressing human antibodies. This person will help characterize the newly created lines of chickens using a variety of molecular and immunological techniques. The Animal Genetics and Molecular Biology group focuses on engineering chickens to produce human antibodies in various formats for different therapeutic applications. New genetically modified lines of chickens are validated in antibody discovery campaigns and the antibodies produced are characterized prior to the chickens being used in partner programs. This individual will collaborate with Antibody Discovery and Protein Sciences groups. The ideal candidate has experience in a range of molecular biology techniques such as PCR, cloning, Western blotting, flow cytometry, and mammalian cell culture.
This role reports to the Senior Director, Molecular Biology.
This is an onsite position based out of our Emeryville headquarters. This is a full-time position, and the working hours are 8am-5pm PT.
What You’ll Do
- Assess B cell development in OmniChickens by flow cytometry, Western blotting, RT-PCR and ELISA.
- Assist in antibody discovery campaigns by preparing immunogens and testing immune responses.
- Perform PCR from single B cells to amplify V regions.
- Clone and express recombinant antibodies in 293 cells and confirm antibody binding by ELISA.
- Produce NGS amplicon libraries for antibody repertoire analysis.
- Clone other constructs as needed.
- Genotype animals by qPCR, looking for errors and inconsistencies, perform troubleshooting and communicate results within short timelines.
- Train team members in established SOPs and best practices.
- Keep accurate and complete notebook entries with effective data management and visualization.
- Maintain inventories of laboratory reagents, recognize and resupply as needed, and communicate low supplies.
- Other duties as required.
What You Bring
- BSc in Molecular Biology or another relevant field and 7+ years of experience.
- Alternatively, MSc in Molecular Biology or another relevant field and 5+ years of experience.
- Technical proficiency across a broad range of molecular biology techniques (i.e. qPCR, Western blotting, ELISA, cell culture).
- Ability to design experiments with proper controls and based on underlying scientific principles and understanding of the project.
- Ability to evaluate experimental outcomes and plan solutions or troubleshoot.
- Ability to present clearly in a group setting.
- Ability to prioritize workflow and multitask with supervision.
- Effective communication, record-keeping and organization skills, and the ability to work in a team environment.
- Eagerness to learn new methods and apply knowledge to a steady stream of new projects with distinct goals.
Nice To Have
- Experience with antibody characterization and/or antibody discovery.
- Experience with transgenic animals.
- Experience with B cell biology.
Our total rewards package includes an annual base compensation, target bonus, equity, refresh grants, ESPP, comprehensive health plans, immediate 401k matching, PTO, sick leave, paid parental leave, commuter benefits, wellness stipend, education reimbursement and more!
The base compensation range for this position is $114,000- $127,000 per year. The range provided is an estimate. Actual compensation may vary based on skills, experience, education, location, and other factors permitted by law.
At OmniAb, we value diversity and strive to create an inclusive environment for everyone. We welcome a variety of experiences, skills, and perspectives within our organization and encourage individuals from diverse backgrounds to apply. We’re proud to be an Equal Opportunity Employer, and we will consider all qualified applicants based on merit and business need. We do not discriminate due to any non-merit-based factors or legally protected classes under federal, state, or local law.