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Associate Scientist/Research Scientist - Protein Sciences

Antibody Discovery | Emeryville, CA | Full Time | From $110,000.00 to $140,000.00 per year

Job Description

The Associate Scientist/Research Scientist position reports to the Director, Protein Sciences supporting OmniAb, Inc. technology platforms, and is responsible for antigen and antibody expression, purification, engineering, and characterization. This position represents strong technical skills and hands-on experience in molecular biology, protein engineering, and antibody developability assessment. Additionally, the role will involve coordinating experiments across a variety of internal and external projects; strong communication skills and collaborative nature are a must. 

The Antibody Discovery group consists of dynamic and innovative scientists that employ a variety of novel platforms to support our partners in discovering the best antibodies possible for their therapeutic applications. At the core of OmniAb is the ability to engineer animals to generate affinity-matured human sequence antibodies for use in conventional and novel formats. We leverage our proprietary animals with state-of-the-art technology in antigen design, immunization methods, and high-throughput single B cell screening to facilitate the discovery of best-in-class antibodies. We are looking for accomplished team players who are enthusiastic to contribute to the technological frontier of antibody discovery, and passionate in their desire to collaborate with partners to develop next-generation therapeutics. See OmniAb.com for more details about the exciting science being performed at OmniAb, Inc. 

About Us:

OmniAb’s discovery platform provides pharmaceutical industry partners access to diverse antibody repertoires and high-throughput screening technologies to enable the discovery of next-generation therapeutics. At the heart of the Ab platform is the Biological Intelligence™ (BI) of our proprietary transgenic animals, including OmniRat, OmniChicken and OmniMouse that have been genetically modified to generate antibodies with human sequences to facilitate the development of human therapeutic candidates. Flic (transgenic rat) and OmniClic (transgenic chicken) address industry needs for bispecific antibody applications though a common light chain approach and OmniTaur features unique structural attributes of cow antibodies for complex targets. We believe the OmniAb animals comprise the most diverse host systems available in the industry and they are optimally leveraged through computational antigen design and immunization methods, paired with high-throughput single B cell phenotypic screening and mining of next-generation sequencing datasets with custom algorithms to identify fully human antibodies with superior performance and developability characteristics. An established core competency focused on ion channels and transporters further differentiate our technology and creates opportunities in emerging target classes OmniAb antibodies have been leveraged across modalities, including bispecific antibodies, antibody-drug conjugates, and others. The OmniAb suite of technologies spans from BI-powered repertoire generation to cutting edge antibody discovery and optimization offering a highly efficient and customizable end-to-end solution for the growing discovery needs of the global pharmaceutical industry.  

Required Experience:

  • Perform antibody/protein engineering to drive therapeutic antibody lead selection, design, and optimization for antibody discovery projects

  • Experience with one or more structural modeling programs such as MOE, Schrodinger, etc.

  • Experience with antibody characterization techniques such as Tm, Tagg, DLS, CE-SDS, cIEF and N-glycan profiling

  • Laboratory experience in protein/antibody purification using various chromatography (affinity, IEX, CEX, SEC, RP) techniques

  • Experience in membrane protein purification and reconstitution is preferred

  • Have expertise and in-depth knowledge of antibodies, bispecifics, and Fc fusion design, expression, and production 

  • Experience in molecular biology, including molecule cloning and protein design

  • Familiar with excipients, stabilizers, and additives to maintain the stability of antibodies

  • Collaborate with internal team members on lab operations and workflow 

 Non-Essential Role Responsibilities Include: 

  • Presentations at major antibody conferences 

  • Mentor Research Associates 

  • Other duties as required 

Requirements: 

  • MS with 4-6+ years’ or PhD with 2+ years relevant experience 

  • Laboratory experience in protein/antibody purification using various chromatography (affinity, IEX, CEX, SEC, RP) techniques is required  

  • Experience with techniques for antibody characterization such as Tm, Tagg, DLS, CE-SDS, cIEF, and N-glycan profiling are required 

  • Experience in antibody cloning and expression is preferred 

  • Eagerness to learn new methods and apply knowledge to a steady stream of new projects with distinct goals 

  • Must demonstrate well-developed communication, record keeping, organizational skills, and the ability to work in a team environment 

Benefits:

The company offers competitive benefits including Medical, Dental, Vision, Short/Long Term Disability and Life Insurance, as well as 401(k) Match, Stock Options, Bonus, and Paid Leave Time. 

Additional Information:

  • All new hires are required to go through background and reference checks

  • OmniAb is an EEO/AA/Disability/Vets employer

  • Must be legally authorized to work in the US without sponsorship

  • OmniAb celebrates the diversity of life and welcomes all individuals to apply

  • New hires based in the US will be required to demonstrate that they have been fully vaccinated and boosted for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement

Base Pay Range:  $110,000 - $140,000/year

 

The pay range provided is an estimated base range for this role. Exact compensation may vary based on skills, experience, education, and location. We also offer an excellent benefits program which includes a selection of Medical and Dental plans, and Life, AD&D and Short-Term Disability insurance, Tuition Reimbursement, 401(k) with immediate Company match vesting, Company paid holidays, and more!


OmniAb, Inc. is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.