Director, Evidence Generation Strategy and Operations

Who we are…

Nuvation Bio is a biopharmaceutical company tackling some of the greatest unmet needs in oncology by developing differentiated and novel therapeutic candidates. Our vision is to significantly change the practice of oncology by developing medicines that provide truly meaningful improvements in quality of life and survival for people with cancer.

What you’ll be doing

Nuvation Bio is seeking a strategic and execution-oriented Director, Evidence Generation Strategy and Operations to lead the planning, prioritization, and operational oversight of all non-registrational evidence generation activities across our oncology portfolio. This role will serve as a matrix leader across Medical Affairs, Clinical Development, Commercial, Market Access, HEOR, and external collaborators to ensure an integrated evidence generation strategy that supports lifecycle management, differentiation, and value demonstration for our commercial-stage product and late-stage pipeline asset.

You will be responsible for…

• Evidence Generation Strategy
  • Partner with Medical Strategy Leads to develop and maintain integrated Evidence Generation Plans (EGPs) across the oncology portfolio, ensuring alignment with lifecycle management objectives.
  • Identify and prioritize evidence gaps across clinical, economic, and real-world settings to inform evidence generation investments.
  • Partner with Clinical Development, Commercial, and Market Access to align evidence strategies with product differentiation and value demonstration goals.
  • Translate strategic business and scientific objectives into actionable evidence-generation initiatives.
• Matrix Leadership & Cross-Functional Collaboration
  • Serve as a matrix leader across internal functions including:
    • Medical Affairs
    • Clinical Development / Clinical Operations
    • Biostatistics / Data Science
    • HEOR / Market Access
    • Commercial / Marketing
    • Legal / Compliance
    • Alliance / Business Development
  • Facilitate governance, prioritization, and decision-making forums for evidence generation programs.
  • Drive alignment across internal stakeholders and external partners on study priorities, timelines, and deliverables.
• Investigator-Initiated and Collaborative Research Oversight
  • Oversee strategy, intake, review, prioritization, and tracking of Investigator-Sponsored Research (ISRs).
  • Partner with Medical Strategy Leads, Field Medical and external investigators to ensure studies align with scientific and business priorities.
  • Lead or support collaborative research initiatives with academic institutions, cooperative groups, and research networks.
  • Ensure proper oversight of budgets, milestones, contracts, and deliverables for externally sponsored research.
• HEOR & Real-World Evidence (RWE)
  • Provide coordination and operational oversight for HEOR and RWE studies, including:
    • Burden of illness studies
    • Treatment pattern analyses
    • Comparative effectiveness research
    • Economic models / cost-effectiveness analyses
    • Retrospective/prospective observational studies
    • Patient-reported outcomes / quality-of-life research
• Partner with Market Access and HEOR teams to generate evidence supporting payer engagement and reimbursement strategies.
• Evaluate and recommend data sources, research partners, and methodologies for RWE generation.
• Program & Operational Management
  • Build and manage evidence-generation operational processes, governance, and tracking systems.
  • Oversee study timelines, budgets, contracts, milestones, and vendor management.
  • Establish KPIs and dashboards to monitor portfolio performance and communicate progress to leadership.
  • Ensure studies are conducted in compliance with internal SOPs, regulatory guidance, and applicable laws.

What Knowledge & Experience you'll bring to us...

• 10+ years of relevant experience in Medical Affairs, Evidence Generation, HEOR, RWE, Clinical Research, or related functions within biotech/pharma.
• Experience in oncology strongly preferred.
• Demonstrated experience leading non-registrational evidence generation strategies across marketed and/or late-stage products.
• Experience managing or overseeing ISR programs, collaborative research, and/or externally sponsored studies.
• Experience managing RWE and HEOR projects inclusive of evidence generation frameworks.
• Strong understanding of the role of evidence in medical, payer, and commercial decision-making.
• Proven ability to lead in a matrixed organization without direct authority.
• Strong program management and operational execution skills.
• Preferred
• Advanced degree preferred: PharmD, PhD, MD, MPH, or MS in life sciences, epidemiology, public health, health economics, or related field.
• Experience in a commercial-stage biotech or fast-paced, growth-stage environment.
• Experience supporting product launch / pre-launch evidence planning.
• Familiarity with global evidence generation considerations.
• Alliance Management experience.
• Experience working with oncology-specific real-world datasets and registries.

Key Competencies

• Strategic thinking and prioritization
• Executive presence and communication
• Cross-functional influence and collaboration
• Operational rigor and attention to detail
• Scientific and business acumen
• Problem-solving and adaptability
• Vendor and budget management

Behavioral skills to be successful...

• Problem-Solver - As an action-oriented self-starter, you’re eager to apply your expertise in diagnosing inefficiencies, determining root causes, and recommending solutions to complex challenges.
• Personable - You establish and nurture highly effective relationships with colleagues and key stakeholders that support and advance project goals and objectives.
• Credible - Thorough understanding of clinical methodologies and providing sound analytical support, you quickly establish credibility as a reliable resource.
• Emotional intelligence, curiosity, and a knack to figure out a way to build something better
• Communication - Effectively listens, conveys, and receives ideas. Maintains a consistent flow of information. A strong presenter and effective communicator with the ability to influence stakeholders.
• Accountability - Acts with a clear sense of ownership - whether the task is in their role description. Holds yourself and others accountable to execute all tasks at hand through seen and unforeseen circumstances with high quality and integrity.
• Adaptability - Can manage in an environment of ambiguity. Embraces the change of a new system, process, technology, or idea in the organization. You could reassess priorities, alter goals and take risks.

What we have for you!

• Competitive Base Salary, Bonus, and Equity Plans
• Unlimited Vacation and 10 Sick Days Annually
• Excellent Medical, Dental, and Vision Coverage
• 401K with Company Matching
• and much more!

The base pay offered will take into account internal equity and also may vary depending on the candidate’s job-related knowledge, skills, experience, and location among other factors. Our full-time regular positions also include an annual performance-based bonus and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, depending on the level and position offered.

Disclaimer

Nuvation Bio, Inc. is an equal opportunity employer, and, in accordance with applicable federal, state, and/or local law, all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, genetic information, national origin, protected veteran status, disability status, or any other characteristic protected by the law.

This job description reflects the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities, and qualifications required of employees assigned to this job. Nothing restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Note to all external Recruiters & Staffing Agencies
All of our open positions are managed by our Talent Acquisition department. Any resumes submitted through the website or directly by recruiters or staffing agencies in advance of an executed agreement with Nuvation Bio, Inc., will be considered unsolicited and the company will not be responsible for any related fees. Resumes sent directly to employees or hiring managers will also not be accepted as referrals.