Scientist/Sr. Scientist, Process Development

About Us:

Eureka Therapeutics, Inc. is a privately held clinical-stage biotechnology company focused on developing novel T-cell therapies to treat cancers. Its core technology centers around its proprietary ARTEMIS® cell receptor platform and E-ALPHA® antibody discovery platform for the discovery and development of potentially safer and more effective T-cell therapies for the treatment of solid tumors and hematologic malignancies. The company currently has two clinical programs, ET140203 (ARYA-1 for adults and ARYA-2 for pediatrics) and ECT204 (ARYA-3), in Phase I/II US trials in patients with advanced liver cancer.

Eureka Therapeutics, Inc. is headquartered in the San Francisco Bay Area. For more information on Eureka, please visit www.eurekatherapeutics.com. ARTEMIS and E-ALPHA are registered trademarks owned by Eureka.

Job Description:

The Scientist/Sr. Scientist, Process Development will work in the Clinical T-Cell Manufacturing (CTCM): Product Development group in Clinical Development. As a key member of the Clinical Development team, the candidate will contribute to the development of Eureka’s vector and T-cell manufacturing processes. In addition, he/she will provide key support to other activities across the Company’s product pipeline programs.

Responsibilities include supporting the implementation and development of successful GMP operations utilizing contract and in-house vector and cell manufacturing facilities.

Responsibilities:

• Contributes independently to the development of T cell and/or viral vector manufacturing processes
• Independently designs, plans and executes studies to support the optimization of the T cell and/or viral vector manufacturing process and to enable clinical trials
• Participates in and leads routine viral vector and/or T cell manufacturing, working closely with Contract Manufacturing Organization and in-house manufacturing team for the technology transfer and troubleshooting of current processes, which requires traveling between facilities (10-30%)
• Supports and drives process characterizations, ranging from the design, management and execution of the laboratory studies (in house and with vendors), in order to achieve a thorough understanding of operation and performance parameters
• Development and hands-on execution of cell-free and multiplexed cell-based assays (e.g. flow cytometry, cytokine release & killing assays) to characterize viral vector and T cell products, to support process development and early product characterization
• Exercises independent judgment in development of new methods, techniques, and evaluation criteria
• Drafts, reviews and amends standard operating procedures (SOPs) for manufacturing process and product characterization
• Generation of notebooks, protocols and other technical documentation
• Other duties as assigned

Minimum Qualifications:

• Ph.D. Degree in Biotechnology, Biochemical Engineering, Cell Biology or related discipline with pharmaceutical/biotech manufacturing & process development experience preferred.
• Minimum of 2 years of related experiences; experience in bioengineering is highly preferred.
• Working knowledge with cGMP manufacturing and regulatory requirements for biological products.
• Hands-on experience in T-cell biology and or virology required with working knowledge of engineering principles.
• Cell culture and aseptic processing experience required.
• Hands-on experience in operating closed system bioprocessing unit preferred (e.g. Xuri/WAVE, CliniMACS, Prodigy, Sefia & Sepax)
• Clear, concise and detail-oriented technical writing.
• Excellent interpersonal, verbal and written communication skills.
• Ability to work in a dynamic environment of a scientifically driven biotech and able to plan and execute simultaneously.
• Ability to evaluate and resolve complex problems.

For the best fit, the candidate should be a fast learner who is detail-oriented and results-driven with outstanding organizational skills, and a team player with strong interpersonal and communications skills and capable of working collaboratively with colleagues. The candidate should be comfortable in a fast-paced environment, able to adjust workload based upon changing priorities and willing to take on additional responsibilities outside of initial job description.

To Apply:

Please submit your resume or CV and cover letter to Jobscore. All submissions will be evaluated, and interviews will be conducted for those applicants who most strongly fit our needs. If you are not contacted for an interview, your resume will remain on file and active for available positions for a period of one year.

Eureka Therapeutics is an equal opportunity employer and does not discriminate against otherwise qualified applicants on the basis of race, religion, color, sex, age, ancestry, national origin, marital status, veteran status, medical conditions, handicap, physical or mental disability, sexual orientation, or any other status protected by law.

If you are a recruiter or placement agency, please do not submit resumes to any employees at Eureka Therapeutics, Inc. prior to having a signed agreement. Eureka Therapeutics is not liable for and will not pay agency fees for candidates submitted by any agency other than its approved recruitment partners. Furthermore, any resumes sent to us without an agreement in place will be considered your company’s gift to Eureka Therapeutics and may be forwarded to our recruiters for their attention.