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Scientist II, Medicinal Chemistry

Research & Development | Mountain View, CA | Full Time

Job Description

Position Overview

ChemoCentryx is seeking a highly talented and motivated scientist to join our small molecule drug discovery team.  The successful candidate with a deep passion for drug discovery and a track record of accomplishments will play a key role in building our expanding pipeline of promising therapeutics.  


Essential Duties and Responsibilities:

  • As a lead scientist, establish project goals/scientific strategies and effectively drive the medicinal chemistry efforts to meet aggressive corporate timeline
  • Closely follow emerging results of biological testing, ADME characterization, and other lead profiling assays; conceive and execute new scientific strategies for the rapid optimization and improvement of key drug attributes
  • Proactively gain competitive intelligence using available resources and incorporate this knowledge into internal drug discovery programs
  • Regularly provide medicinal chemistry and project updates to a multidisciplinary drug discovery team and senior management
  • Maintain a high level of productivity in the laboratory as evidenced by consistently generating high-impact compounds
  • Lead and contribute to the writing of patent applications, study reports, and scientific publications
  • Position may involve management of direct reports, depending on level of experience



  • PhD in organic chemistry or equivalent with at least 3 years of medicinal chemistry experience in pharmaceutical industry
  • Extensive knowledge of synthetic organic chemistry and superior problem solving skills; experience in designing and executing multistep synthesis of complex organic molecules using modern techniques in organic chemistry
  • Solid understanding and application of pharmacology, PK/PD, and ADME concepts
  • Ability to independently identify and promptly resolve core project challenges by effectively utilizing available information and scientific expertise
  • Demonstrated success in lead optimization, structure-activity relationship analysis, and property-oriented drug design, leading to development candidate nomination
  • Enthusiastic, high energy, and collaborative team player with strong ability to build productive relationships with scientists in the chemistry department and other disciplines to enable high individual performance and team success
  • Exceptional oral communication and writing skills
  • Previous supervisory and project leading experience highly preferred