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Research Associate-Cell Culture

R&D | St. Louis, MO | Full Time

Job Description

Position Description

Research Associate- Cell Culture



At Arch Oncology, we are aiming high to discover and develop new antibody therapeutics to treat patients living with cancer. Our best-in-class anti-CD47 antibody, AO-176, is highly differentiated, with the potential to improve upon the safety and efficacy profile relative to other agents in this class.  AO-176 works by blocking the “don’t eat me” signal, the standard mechanism of anti-CD47 antibodies. Importantly, it has lower binding to normal cells compared to tumor cells and binds more potently to tumors in their acidic microenvironment (low pH), offering a potential safety advantage. Beyond blocking this signal, AO-176 also directly kill tumor cells and induces immunogenic cell death.  AO-176 is currently in multiple Phase 1 clinical trials for the treatment of patients with solid tumors and multiple myeloma. Behind AO-176, our research team is developing a pipeline of antibodies with best-in-class profiles for the treatment of patients with cancer.

We are aiming high in the fight against cancer. We are a team of highly experienced and driven professionals who are committed to excellence in all that we do. If you share this commitment and want to work with a team focused on improving the lives of cancer patients, aim high with us and apply.


Position Location:

At Arch Oncology, we have two locations. Our headquarters is in Brisbane, CA, a gateway of biotechnology innovation, and our scientific research laboratory is in St. Louis, MO, home of the Gateway Arch. This position is located in St. Louis, MO.


Reports To: 

Sr Scientist


Job Description and Responsibilities:


The Research Associate-Cell Culture will be the primary point person performing cell culture for use in cell-based assays and in vivo studies. The successful candidate must have the skills to handle multiple cell lines of differing origins and characteristics (human and mouse, suspension, adherent, primary, stable transient).


  • Plan, schedule and coordinate cell growth and production to meet experiment timelines.
  • Prepare master and working cell banks.
  • Create cryopreserved cell stocks and manage cell line inventories.
  • Maintain the tissue culture facility in a safe and well running manner.
  • Coordinate supply orders for cell culture to ensure continued productivity.
  • Keep detailed records of cell culture methods and results.
  • Participate in lab meetings and present work to a team of scientists.
  • Generate, analyze, and record experimental data.
  • As available, assist in experiments including, but not limited to, flow cytometry, ELISA, recombinant cell creation/characterization, transient and stable cell protein production.


Position Requirements and Experience: 


·      B.S. biological sciences and preferably cancer biology, pharmacology, immunology, or related discipline.

·      3 years prior work experience required, industry preferred.

·      Experience in mammalian cell culture, assays, and aseptic technique; transfection and stable cell line production.

·      Flow cytometry or cell-based assay experience a plus.

·      Strong collaborative skills; well-organized; goal oriented; effective in a multidisciplinary team environment.

·      A strong work ethic, drive, pro-activeness, and ability to execute and multi-task activities with minimal supervision.

·      Strong problem-solving, analytical and documentation skills.

·      Excellent written and verbal communication skills.

·      Exemplifies honesty, ethics, and integrity.




Arch Oncology offers a generous benefits package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan.


Arch Oncology is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.