R&D | St. Louis, MO | Full Time
At Arch Oncology, we are aiming high to discover and develop new antibody therapeutics to treat patients living with cancer. Our best-in-class anti-CD47 antibody, AO-176, is highly differentiated, with the potential to improve upon the safety and efficacy profile relative to other agents in this class. AO-176 works by blocking the “don’t eat me” signal, the standard mechanism of anti-CD47 antibodies. Importantly, it has lower binding to normal cells compared to tumor cells, and binds more potently to tumors in their acidic microenvironment (low pH), offering a potential safety advantage. Beyond blocking this signal, AO-176 also directly kill tumor cells and induces immunogenic cell death. AO-176 is currently in multiple Phase 1 clinical trials for the treatment of patients with solid tumors and multiple myeloma. Behind AO-176, our research team is developing a pipeline of antibodies with best-in-class profiles for the treatment of patients with cancer.
We are aiming high in the fight against cancer. We are a team of highly experienced and driven professionals who are committed to excellence in all that we do. If you share this commitment and want to work with a team focused on improving the lives of cancer patients, aim high with us and apply.
At Arch Oncology, we have two locations. Our headquarters is in Brisbane, CA, a gateway of biotechnology innovation, and our scientific research laboratory is in St. Louis, MO, home of the Gateway Arch. This position is located in St. Louis, MO.
Job Description and Responsibilities:
The Animal Technician functions as a key member of a team of scientists evaluating the in vivo efficacy of drug candidates. This involves establishing growth characteristics of different tumors, drug administration, tumor and clinical sign monitoring and animal care, all in accordance with IACUC approved procedures. Minor surgical procedures may also be performed in addition to necropsy and tissue retrieval for analysis. Data recording and strong attention to details and the ability to function in a team environment are vital to this position.
· Performs the daily care of research animals for experimental purposes, which may include cleaning cages and racks.
· Assists with in vivo studies to assess the research stage antibodies therapeutic potential.
o Caliper-based tumor measurements
o Inoculating and drug administration via multiple routes (IV, IP)
· As needed, perform molecular, biochemical, and biologic techniques for discovery and in vitro characterization of anti-cancer antibodies. (ex. Flow cytometry, ELISA, Western Blotting, cell-based assays etc.).
· Coordinates with vendors and supervisors on operational, administrative, and technical responsibilities.
· Responsible for overseeing procurement of animals and supplies, preventive maintenance of facility equipment, daily rounds and observation to check animal health status.
· Follows standard operating procedures and maintains records to comply with regulatory requirements.
Position Requirements and Experience:
· B.S biological sciences and preferably cancer biology, pharmacology, immunology, or related discipline.
· 3 years prior work experience required, industry preferred.
· Experience in animal handling, tumor measurements, cell culture, drug administration, in vivo study design
· Flow cytometry or cell-based assay experience a plus
· Strong collaborative skills; well-organized; goal oriented; effective in a multidisciplinary team environment.
· A strong work ethic, drive, pro-activeness, and ability to execute and multi-task activities with minimal supervision.
· Excellent attention to detail and documentation skills.
· Strong problem-solving and analytical skills.
· Excellent written and verbal communication skills.
· Exemplifies honesty, ethics, and integrity.
Arch Oncology offers a generous benefits package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan.
Arch Oncology is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.