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Sr. Assoc. Sci/Assoc. Sci, Process Development Viral Vector

Process and Product Development | South San Francisco, CA | Full Time

Job Description

About Allogene Therapeutics, Inc:

Allogene Therapeutics is a clinical-stage biotechnology company with a single-minded focus on pioneering the development of investigational allogeneic chimeric antigen receptor T cell (AlloCAR T™) products for cancer. Led by world-class management with significant experience in cell therapy, our fully integrated, in-house team of researchers is dedicated to discovery and translational research, development, and cell manufacturing.

At Allogene, we are developing a pipeline of off-the-shelf CAR T cell candidates, with the goal of delivering readily available cell therapy faster, more reliably, and at greater scale to more patients. For more information, please visit, and follow @AllogeneTx on Twitter and LinkedIn.

Job Description:

Allogene is seeking an Associate Scientist or Senior Associate Scientist to join the viral vector group within Process Development. The viral vector group is responsible for the production processes and characterization methods of the viral vectors used in Allogene’s CART therapies. The viral vector team also works closely with internal and external partners to support the clinical manufacturing of viral vectors.

The individual in this role will contribute to the development, implementation and characterization of state-of-the-art processing technologies to deliver scalable and robust manufacturing processes and support successful tech transfer for GMP manufacturing and release at a CMO. This position will also contribute to the development of novel technologies and approaches to meet future CART manufacturing needs.

Responsibilities include, but are not limited to:

  • Actively contribute to development, implementation, characterization and successful execution of robust, state-of-the-art viral vector manufacturing processes.
  • Support clinical-scale non-GMP and IND-enabling manufacturing operations, including Tech Transfer to CMO and support of successful GMP manufacturing of clinical material.
  • Contribute to innovation programs to enhance vector manufacturing technologies and capabilities (such as alternate transfection/ transduction/ cell engineering strategies, formulation development, filling and container optimization), aligned with emerging business drivers and regulatory expectations.
  • Contribute to Project Technical Teams and communicate and collaborate effectively to ensure effective interactions with all stakeholder groups.
  • Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports.
  • Summarize and present data in Project Team meetings
  • Remain current with the process engineering and chemistry literature. Collaborate and author external publications and present research at external conferences.

Position Requirements & Experience:

  • MS or BS in Chemical Engineering, Biochemistry, Molecular & Cell Biology, Immunology or the related field with 0-4 years (with MS) or 0-7 years (with BS) of relevant experience required.
  • A demonstrated understanding of mammalian or primary cell culture, biochemistry, molecular & cell biology, virology, and immunology.
  • Experience with development of filtration (dead-end and TFF) and chromatography-based processes
  • Experience with process characterization studies
  • Experience with formulation development and methods for viral vector quantitation and characterization
  • Experience with stability studies and data analysis
  • Experience in DOE methodologies preferred, but not required.
  • Experience with continuous manufacturing processes including operation in upstream genetic modification and bioreactor/WAVE expansion, and cryopreservation.
  • Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously.
  • Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.
  • Ability to work independently and as part of a team.
  • Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment.
  • Candidates must be authorized to work in the U.S.

As an equal opportunity employer, Allogene is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment and internships designed to create a stronger and better Allogene that is focused on developing life-changing products for patients.