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Scientist, Protein Sciences and Analytics

Research | South San Francisco, CA | Full Time

Job Description

Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.

Job Description: 

Allogene Therapeutics is seeking a highly motivated Scientist in Protein Engineering to support the protein expression, purification and analysis needs across all our research and development programs. The successful candidate will report directly to the Head of Protein Engineering and be responsible for continuing our development and implementation of these core capabilities in support of our pipeline of allogeneic CAR T cells. The ideal candidate is an individual who is interested in working in a fast-paced, dynamic and highly collaborative start-up environment with a willingness and ability to successfully take on new challenges. 

Responsibilities include, but are not limited to

  • Maintain mammalian cell lines for transient transfection of plasmid DNA 
  • Express and purify a variety of proteins including monoclonal antibodies, antibody fragments, antigens and chimeric/fusion proteins
  • Perform protein analytics with a focus on protein interactions using SPR (Biacore) 
  • Deliver protein preparations and data analysis summaries in a timely manner to the project team 
  • Design, execute and troubleshoot protein purification and analytical protocols 
  • Help maintain laboratory instrumentation to ensure proper functioning 
  • Stay abreast of latest scientific and technology advancements in the field 
  • Other duties as assigned 

Requirements: 

  • Bachelor’s degree in Biochemistry or related discipline with 8+ years experience OR Master’s degree in Biochemistry or related discipline with 5+ years post-graduate experience 
  • Experience with protein expression using mammalian cells is preferred. Prior experience with Expi293 is preferred. 
  • Experience with a variety of FPLC based chromatography techniques including Protein A, IMAC, IEX and SEC is preferred. 
  • Prior experience with AKTA Avant and Unicorn software is preferred 
  • Experience with protein analytical techniques such as SDS-PAGE, HPLC, SEC-MALS, and DSC is preferred
  • Experience with SPR (Biacore) is required 
  • Meticulous and highly organized as it pertains to experimental design, bench-work, record keeping and data analysis 
  • Excellent organizational skills and an ability to prioritize effectively to deliver high quality results within reasonably established timelines 
  • Strong interpersonal skills including verbal and written communication, relationship building, and conflict resolution are essential in this collaborative work environment 
  • Ability to effectively work in a fast-paced, start-up environment, while dealing with ambiguity 
  • Desire and ability to learn required skills quickly 
  • Candidates must be authorized to work in the U.S 

As an equal opportunity employer, Allogene Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.

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