Principal Scientist, Allogeneic CAR T cells
Research | South San Francisco, CA | Full Time
Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T™) therapies for cancer. Led by a world-class management team with significant experience in cell therapy, Allogene is developing a pipeline of “off-the-shelf” CAR T cell therapy candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.
Job Description and Responsibilities:
Allogene Therapeutics is seeking an independent and highly motivated Scientist to conduct preclinical studies to evaluate and improve the efficacy of allogeneic CAR T cell therapies. The candidate will provide scientific and technical expertise to study CAR T cells in the allogeneic environment and investigate modifications that enhance their persistence and activity. The ideal candidate is an individual who is excited to take on new challenges in a dynamic start-up environment.
- Design and execute in vitro assays to assess T and NK cell alloreactivity
- Plan and conduct studies to monitor immune reconstitution and allogeneic CAR T cell persistence and activity following lymphodepletion in immunocompetent mouse models
- Investigate genetic modifications that may prevent alloreactivity and/or sustain the persistence of CAR T cells in the allogeneic environment
- Contribute to a collaborative group effort to advance next-generation AlloCAR T cell therapies into the clinic
- Collaborate with the CAR T cell process development group to inform future manufacturing process improvements for allogeneic CAR T cells
- Stay abreast of latest scientific and technology advancements in the field
- Train and mentor junior scientists and perform other duties as assigned
- Present at group meetings and project team meetings
- PhD or equivalent with 5+ years of post-doctoral experience in immunology or T cell biology
- Knowledge of cellular and molecular immunology
- Relevant experience in immunocompetent mouse models and MLR assays preferred
- Ability to design and execute studies to evaluate mouse and human CAR T cell activity in vitro and in vivo
- Hands-on experience in retroviral/lentiviral transduction of mouse and human T cells preferred
- Knowledge and experience in gene editing technologies including CRISPR/Cas9
- Experience in immune cell isolation and proficiency in flow cytometry-based characterization of immune cells
- Proactive attitude and strong desire to be part of a team working together to overcome obstacles
- Strong oral presentation and communication skills
- Candidates must be authorized to work in the U.S.
As an equal opportunity employer, Allogene Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact the careers email at www.allogene.com for assistance.
For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.