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Associate Scientist/Scientist, Protein Science/Antibody Engineer

Research | South San Francisco, CA | Full Time

Job Description

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About Allogene Therapeutics, Inc:

Allogene Therapeutics is a clinical-stage biotechnology company with a single-minded focus on pioneering the development of investigational allogeneic chimeric antigen receptor T cell (AlloCAR T™) products for cancer. Led by world-class management with significant experience in cell therapy, our fully integrated, in-house team of researchers is dedicated to discovery and translational research, development, and cell manufacturing.

At Allogene, we are developing a pipeline of off-the-shelf CAR T cell candidates, with the goal of delivering readily available cell therapy faster, more reliably, and at greater scale to more patients. For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.


About the role:

Allogene Therapeutics is seeking a highly motivated Associate Scientist/ Scientist in the Protein Science group to support the antibody/protein engineering, production, conjugation, and characterization needs across all our research and development programs. The position will report to the Sr Principal Scientist, Protein Engineering and be responsible for continuing our development and implementation of these core capabilities in support of our pipeline of allogeneic CAR T cells. The ideal candidate is an individual who is interested in working in a fast-paced, dynamic, and highly collaborative biotech environment with a willingness and ability to successfully take on new challenges.

Responsibilities include, but are not limited to:

  • Maintain mammalian cell lines for transient transfection of plasmid DNA
  • Express and purify a variety of proteins including monoclonal antibodies, antibody fragments, antigens, and chimeric/fusion proteins
  • Oversee antibody campaigns, screening, engineering, and production at CROs
  • Perform protein conjugation, labeling, and analytics such as HPLC-SEC, SEC-MALS, SPR (Biacore), ELISA, SDS-PAGE et al.
  • Deliver protein preparations and data analysis summaries in a timely manner to the project team
  • Design, execute and troubleshoot protein purification and analytical protocols
  • Help maintain laboratory instrumentation to ensure proper functioning
  • Stay abreast of latest scientific and technology advancements in the field
  • Other duties as assigned

Position Requirements & Experience:

  • BS. or MS. degree in life science or related field required (or relevant experience) and 1+ years of experience in similar role in biotechnology industry
  • Meticulous and highly organized as it pertains to experimental design, bench-work, record keeping and data analysis
  • Desire and ability to learn required skills quickly
  • Having deep understanding and hands on experience with monoclonal antibody discovery workflow is highly preferred
  • Experience with a variety of FPLC based chromatography techniques including Protein A, IMAC, IEX and SEC
  • Experience with protein expression using mammalian cells or insect cells
  • Experience with designing, executing, and analyzing SPR/Biacore experiments
  • Experience with protein analytical techniques such as HPLC and SEC-MALS
  • Ability to effectively work in a fast-paced, biotech environment, while dealing with ambiguity
  • Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines.
  • Ability to work independently and as part of a team.
  • Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment.
  • Candidates must be authorized to work in the U.S.


As an equal opportunity employer, Allogene is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment and internships designed to create a stronger and better Allogene that is focused on developing life-changing products for patients.

Please be aware that the FBI recently issued a warning about an increased number of fake job postings for remote work employment that target applicants' personally identifiable information. All approved Allogene Therapeutics positions are accessible via the Allogene Careers page at www.allogene.com/careers.

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